Hi Ray
Day to day work has not shown up any real difference had to reinstall a few drivers on usb camera etc, but that was to be expected.
As far as the kernel is concerned I don't think it has been fully re-engineered from what i have seen, however a number of API's have been introduced which should help the independent software vendors to run there software on 64-bit PC's.
For full info on whats been done see link
http://download.microsoft.com/download/9/c/5/9c5b2167-8017-4bae-9fde-d599bac8184a/kernel-en.doc
scottbelton@tiscali.co.uk